منابع مشابه
Clinical benefits of low serum digoxin concentrations in heart failure.
OBJECTIVES We sought to determine whether there was a relationship between serum digoxin concentration (SDC), including SDCs typically regarded as low, and clinical efficacy related to digoxin in patients with symptomatic left ventricular dysfunction. BACKGROUND Digitalis glycosides have been used for 200 years in the treatment of heart failure (HF), but the SDC required for optimal clinical ...
متن کاملSome observations on serum concentrations of digitoxin and digoxin.
Serum concentrations of digitoxin and digoxin were measured in 145 cases with various heart diseases receiving maintenance doses of digitalis. Digitalis toxicity was seen in only 2 cases (1.4%). Day-to-day variation of serum concentration while taking the same daily dose was small in digitoxin therapy (13.8%), but a considerable variation was seen in digoxin therapy (24.4%). Serum concentration...
متن کاملEffects of maintenance digoxin therapy on systolic time intervals and serum digoxin concentrations.
or 0.5 mg/day for alternate two-week periods without a loading dose. Control data were obtained both before and after the four weeks of treatment. After 13 days treatment with digoxin, 0.5 mg/day, there was a significant decrease in total electromechanical systole corrected for heart rate (QS2i), pre-ejection period (PEP), pre-ejection period corrected for heart rate (PEP,) and PEP/left ventric...
متن کاملCorrelation of serum concentrations with heart concentrations of digoxin in human subjects.
THE UTILITY OF THE ASSAY of serum levels of a drug implies a systematic relationship between this measurement and concentration of the drug at the site of action during "steady state" conditions. Data to support this relationship with respect to digoxin have been sparse, particularly with respect to man. One noteworthy finding is the observation both in animals' and in man2 that digoxin concent...
متن کاملAssessment of Abnormal Serum Digoxin Concentration
ABSTRACT Cardiac glycosides have been used in the management of heart failure for more than 200 years and remain the only drug currently available for Long-term ambulatory use that have positive inotropic effect. The relatively narrow therapeutic- index of cardiac glycosides renders them particularly difficult to use, and the clinician should have a detailed understanding of the actions and ph...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1976
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1976.tb04897.x